This is a very good question. So depends, this depends a lot on which joint or what area of the body has been treated and also by which treatment. So typically a patient that is undergone STEM cell treatment into their knees will be asked to not walk for the, or not weight bear excessively for the next 48 hours. Typically they will be out of action for two days, and the next seven days they’re going to understand that something’s happening in their body. After seven days, most of our patients feel as as good as they were before, if not start to feel better and better and better. With regards to growth factor injections, typically when we do this, they do leave a residual discomfort, particular first injection for up to 7 days.